Publications of Sarah E. O’Connor

Payne, R. M. E.; Xu, D.; Foureau, E.; Carqueijeiro, M. I. S. T.; Oudin, A.; de Bernonville, T. D.; Novak, V.; Burow, M.; Olsen, C.-E.; Jones, D. M. et al.; Tatsis, E. C.; Pendle, A.; Halkier, B. A.; Geu-Flores, F.; Courdavault, V.; Nour-Eldin, H. H.; O’Connor, S. E.: An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole. Nature 3, 16208 (2017)

Alagna, F.; Geu-Flores, F.; Kries, H.; Panara, F.; Baldoni, L.; O'Connor, S. E.; Osbourn, A.: Identification and characterization of the iridoid synthase involved in oleuropein biosynthesis in olive (Olea europaea) fruits. The Journal of Biological Chemistry 291 (11), pp. 5542 - 5554 (2016)

Jakubczyk, D.; Caputi, L.; Stevenson, C. E. M.; Lawson, D. M.; O'Connor, S. E.: Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis. Chemical Communications 52 (99), pp. 14306 - 14309 (2016)

Kries, H.; Caputi, L.; Stevenson, C. E. M.; Kamileen, M. O.; Sherden, N. H.; Geu-Flores, F.; Lawson, D. M.; O'Connor, S. E.: Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nature Chemical Biology 12 (1), pp. 6 - 8 (2016)

Kries, H.; O'Connor, S. E.: Biocatalysts from alkaloid producing plants. Current Opinion in Chemical Biology 31, pp. 22 - 30 (2016)

Parage, C.; Foureau, E.; Kellner, F.; Burlat, V.; Mahroug, S.; Lanoue, A.; Duge de Bernonville, T.; Arias Londono, M.; Carqueijeiro, I.; Oudin, A. et al.; Besseau, S.; Papon, N.; Glevarec, G.; Atehortua, L.; Giglioli-Guivarc'h, N.; St-Pierre, B.; Clastre, M.; O'Connor, S. E.; Courdavault, V.: Class II cytochrome P450 reductase governs the biosynthesis of alkaloids. Plant Physiology 172 (3), pp. 1563 - 1577 (2016)

Stavrinides, A.; Tatsis, E. C.; Caputi, L.; Foureau, E.; Stevenson, C. E. M.; Lawson, D. M.; Courdavault, V.; O'Connor, S. E.: Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity. Nature Communications 7, 12116 (2016)

Tatsis, E. C.; O'Connor, S. E.: New developments in engineering plant metabolic pathways. Current Opinion in Biotechnology 42, pp. 126 - 132 (2016)

Brown, S.; Clastre, M.; Courdavault, V.; O'Connor, S. E.: De novo production of the plant-derived alkaloid strictosidine in yeast. Proceedings of the National Academy of Sciences of the United States of America 112 (11), pp. 3205 - 3210 (2015)

Brown, S.; O'Connor, S. E.: Halogenase engineering for the generation of new natural product analogues. Chembiochem 16 (15), pp. 2129 - 2135 (2015)

de Bernonville, T. D.; Foureau, E.; Parage, C.; Lanoue, A.; Clastre, M.; Londono, M. A.; Oudin, A.; Houille, B.; Papon, N.; Besseau, S. et al.; Glevarec, G.; Atehortua, L.; Giglioli-Guivarc'h, N.; St-Pierre, B.; De Luca, V.; O'Connor, S. E.; Courdavault, V.: Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome. BMC Genomics 16, 619 (2015)

Jakubczyk, D.; Caputi, L.; Hatsch, A.; Nielsen, C. A. F.; Diefenbacher, M.; Klein, J.; Molt, A.; Schroeder, H.; Cheng, J. Z.; Naesby, M. et al.; O'Connor, S. E.: Discovery and reconstitution of the cycloclavine biosynthetic pathwa—enzymatic formation of a cyclopropyl group. Angewandte Chemie International Edition 54 (17), pp. 5117 - 5121 (2015)

Kellner, F.; Geu-Flores, F.; Sherden, N. H.; Brown, S.; Foureau, E.; Courdavault, V.; O'Connor, S. E.: Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids. Chemical Communications 51 (36), pp. 7626 - 7628 (2015)

Kellner, F.; Kim, J.; Clavijo, B. J.; Hamilton, J. P.; Childs, K. L.; Vaillancourt, B.; Cepela, J.; Habermann, M.; Steuernagel, B.; Clissold, L. et al.; McLay, K.; Buell, C. R.; O'Connor, S. E.: Genome-guided investigation of plant natural product biosynthesis. The Plant Journal 82 (4), pp. 680 - 692 (2015)

Munkert, J.; Pollier, J.; Miettinen, K.; Van Moerkercke, A.; Payne, R.; Mueller-Uri, F.; Burlat, V.; O'Connor, S. E.; Memelink, J.; Kreis, W. et al.; Goossens, A.: Iridoid synthase activity is common among the plant progesterone 5β-reductase family. Molecular Plant 8 (1), pp. 136 - 152 (2015)

Patron, N.; Orzaez, D.; Marillonnet, S.; Warzecha, H.; Matthewman, C.; Youles, M.; Raitskin, O.; Leveau, A.; Farre, G.; Rogers, C. et al.; Smith, A.; Hibberd, J.; Webb, A. A. R.; Locke, J.; Schornack, S.; Ajioka, J.; Baulcombe, D. C.; Zipfel, C.; Kamoun, S.; Jones, J. D. G.; Kuhn, H.; Robatzek, S.; Van Esse, H. P.; Sanders, D.; Oldroyd, G.; Martin, C.; Field, R.; O'Connor, S. E.; Fox, S.; Wulff, B.; Miller, B.; Breakspear, A.; Radhakrishnan, G.; Delaux, P.-M.; Loque, D.; Granell, A.; Tissier, A.; Shih, P.; Brutnell, T. P.; Quick, W. P.; Rischer, H.; Fraser, P. D.; Aharoni, A.; Raines, C.; South, P. F.; Ane, J.-M.; Hamberger, B. R.; Langdale, J.; Stougaard, J.; Bouwmeester, H.; Udvardi, M.; Murray, J. A. H.; Ntoukakis, V.; Schaefer, P.; Denby, K.; Edwards, K. J.; Osbourn, A.; Haseloff, J.: Standards for plant synthetic biology: a common syntax for exchange of DNA parts. New Phytologist 208 (1), pp. 13 - 19 (2015)

Stavrinides, A.; Tatsis, E. C.; Foureau, E.; Caputi, L.; Kellner, F.; Courdavault, V.; O'Connor, S. E.: Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism. Chemistry & Biology 22 (3), pp. 336 - 341 (2015)

Van Moerkercke, A.; Steensma, P.; Schweizer, D.; Pollier, J.; Gariboldi, I.; Payne, A.; Bossche, R. V.; Miettinen, K.; Espoz, J.; Purnama, P. C. et al.; Kellner, F.; Seppänen-Laakso, T.; O'Connor, S. E.; Rischer, H.; Memelink, J.; Goossens, A.: The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus. Proceedings of the National Academy of Sciences of the United States of America 112 (26), pp. 8130 - 8135 (2015)

Jakubczyk, D.; Cheng, J. Z.; O'Connor, S. E.: Biosynthesis of the ergot alkaloids. Natural Product Reports 31 (10), pp. 1328 - 1338 (2014)

Lindner, S.; Geu-Flores, F.; Braese, S.; Sherden, N. H.; O'Connor, S. E.: Conversion of substrate analogs suggests a Michael cyclization in iridoid biosynthesis. Chemistry & Biology 21 (11), pp. 1452 - 1456 (2014)